MT-45 [1-cyclohexyl-4-(1,2-diphenylethyl)piperazine], also known as IC-6, NSC 299236 and CDEP, is a synthetic opioid developed as a therapeutic drug candidate in the 1970s by the Dainippon Pharmaceutical Co. in Japan. MT-45 has never been commercially available as a therapeutic agent; however, it has appeared on the illicit recreational drug market in recent years, but not extensively.
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MT-45 (IC-6) is an opioid analgesic drug . It is chemically a 1-substituted-4-(1,2-diphenylethyl)piperazine derivative, which is structurally unrelated to most other opioid drugs. Racemic MT-45 has around 80% the potency of morphine, with almost all opioid activity residing in the (S) enantiomer (the opposite stereochemistry from the related drug lefetamine). It has been used as a lead compound from which a large family of potent opioid drugshave been developed, including full agonists, partial agonists, and antagonists at the three main opioid receptor subtypes.Fluorinated derivatives of MT-45 such as 2F-MT-45 are significantly more potent as μ-opioid receptor agonists, and one of its main metabolites 1,2-diphenylethylpiperazine also blocks NMDA receptors.Buy MT-45 Powder online